There is not a lot of research out there regarding patients quality of life studies on long term TPN.

Of the few studies I’ve found, it seems that the underlying condition is really what impacts the quality of life based on how the patient’s daily symptoms are.

Sources:

1. Jeppesen, P. B., Langholz, E., & Mortensen, P. B. (1999). Quality of life in patients receiving home parenteral nutrition. Gut, 44(6), 844–852. https://doi.org/10.1136/gut.44.6.844.

2. https://digitalcommons.uri.edu/cgi/viewcontent.cgi?article=2036&context=theses

3. Baxter, J. P., Fayers, P. M., & McKinlay, A. W. (2010). The clinical and psychometric validation of a questionnaire to assess the quality of life of adult patients treated with long‐term parenteral nutrition. Journal of Parenteral and Enteral Nutrition, 34(2), 131-142. https://www.semanticscholar.org/paper/The-clinical-and-psychometric-validation-of-a-to-of-Baxter-Fayers/993fb2ac0d7ad0d8ac97fc6cfc5677457c5a9b2d.